Abstract—we synthesized excretable radioactive gold nanoparticles at gum arabic (198AuNPs@GA) for radiotherapy. The nanocomposite of AuNPs@GA was first synthesized by synchrotron X-ray. After neutron activation, the nanocomposite of AuNPs@GA formed radioactive 198AuNPs@GA in which the radioisotope of 198Au can generate β particles (βmax = 960 keV) and gamma ray (Egamma = 412 keV) to kill cancer cells and suppress tumor growth. The efficacy of radiotherapy was evaluated with H460 tumor model by intratumoral injection. At day 7 after intratumoral administration of 198AuNPs@GA, the tumor was significantly suppressed over 90% (P < 0.01), compared to the controls. Intratumoral injection with 198AuNPs@GA did not cause serious weight loss of mice. After 2-weeks observation period, 198AuNPs@GA was still mainly accumulated in the tumor. Interestingly, excretion of 198AuNPs@GA in feces and urine was observed from first day to the endpoint of experiment. In this study, the radioactive 198AuNPs@GA nanocomposite not only successfully suppressed tumor growth but also could be excreted through urine and feces, eliminating possible toxic concerns of nanomaterial accumulation in vivo.
Index Terms—Gold nanoparticles, gum arabic, radiotherapy, synchrotron X-rays irradiation.
F. S. Lin and F. G. Tseng are with Department of Engineering and System Science, National Tsing Hua University, Hsinchu 30013, Taiwan. (e-mail: d9611812@oz.nthu.edu.tw, fangang@ess.nthu.edu.tw)
C. H. Chen, J. K. Chen, S. Y. Lin, and C. S. Yang are with Center for Nanomedicine Research, National Health Research Institutes, Zhunan, Miaoli 35053, Taiwan. (e-mail: 960607@nhri.org.tw, jkchen@nhri.org.tw, 971223@nhri.org.tw, cyang@nhri.org.tw)
Y. H. Wu is with Institute of Physics, Academia Sinica, Nankang, Taipei 115, Taiwan. (e-mail: phhwu@sinica.edu.tw)
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Cite:Fong-Sian Lin, Chien-Hung Chen, Fan-Gang Tseng, Yeukuang Hwu, Jen-Kun Chen, Shu-Yi Lin, and Chung-Shi Yang, "Radiotherapy of the Excretable Radioactive Gold Nanocomposite with Intratumoral Injection," International Journal of Materials, Mechanics and Manufacturing vol. 1, no. 3, pp. 265-268, 2013.
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