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General Information
    • ISSN: 1793-8198
    • Frequency: Quarterly
    • DOI: 10.18178/IJMMM
    • Editor-in-Chief: Prof. K. M. Gupta, Prof. Ian McAndrew
    • Executive Editor: Ms. Cherry L. Chen
    • Abstracting/Indexing: EI (INSPEC, IET), Chemical Abstracts Services (CAS), Engineering & Technology Digital Library,  ProQuest, Crossref, Ulrich's Periodicals Directory, DOAJ, and Electronic Journals Library .
    • E-mail ijmmm@ejournal.net
Editor-in-chief
Prof. Ian McAndrew
Embry Riddle Aeronautical University, UK.
It is my honor to be the editor-in-chief of IJMMM. I will do my best to help develop this journal better.

IJMMM 2014 Vol.2(1): 81-85 ISSN: 1793-8198
DOI: 10.7763/IJMMM.2014.V2.105

Electrospun Nanofiber Matrix with a Mucoadhesive Backing Film for Oramucosal Drug Delivery

Charu Tyagi, Lomas Tomar, Yahya E. Choonara, Lisa C. Du Toit, Pradeep Kumar, and Viness Pillay
Abstract—A rapidly disintegrating oramucosal drug delivery system was prepared with mucoadhesive polymeric backing film. Various polymers were investigated for suitability in the development of electrospun nanofibers layer and different set of polymers for backing film layer. Individual layers and the system with nanofiber spun directly on the backing film were characterized using standard techniques. Ex vivo drug permeation analysis was performed to establish the suitability of the system. Polyvinylalcohol (PVA) produced drug-loaded fibers with the most acceptable morphology and a disintegration time of 5sec. Acceptable films casted were of PVA/hydroxypropylmethylcellulose (HPMC), with required mucoadhesive property and average disintegration time of 7-60sec. Diphenhydramine loaded delivery system exhibited 42-82% drug permeation in study time period potentiating the feasible application of the system for oramucosal drug delivery.

Index Terms—Backing film, electrospun nanofiber matrix, mucoadhesion, oramucosa drug delivery.

The authors are with University of the Witwatersrand, Faculty of Health Sciences, Department of Pharmacy and Pharmacology, 7 York Road, Parktown 2193, Johannesburg, South Africa (e-mail: charu.tyagi@wits.ac.za, lomaskumar.tomar@wits.ac.za, yahya.choonara@wits.ac.za, pradeep.kumar@wits.ac.za, lisa.dutoit@wits.ac.za, vines.pillay@wits.ac.za).

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Cite:Charu Tyagi, Lomas Tomar, Yahya E. Choonara, Lisa C. Du Toit, Pradeep Kumar, and Viness Pillay, "Electrospun Nanofiber Matrix with a Mucoadhesive Backing Film for Oramucosal Drug Delivery," International Journal of Materials, Mechanics and Manufacturing vol. 2, no. 1, pp. 81-85, 2014.

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