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General Information
    • ISSN: 1793-8198 (Print)
    • Abbreviated Title: Int. J. Mater. Mech. Manuf.
    • Frequency: Bimonthly
    • DOI: 10.18178/IJMMM
    • Editor-in-Chief: Prof. Ian McAndrew
    • Co-editor-in-Chief: Prof. K. M. Gupta
    • Executive Editor: Cherry L. Chen
    • Abstracting/Indexing: EI (INSPEC, IET), Chemical Abstracts Services (CAS),  ProQuest, Crossref, Ulrich's Periodicals Directory,  EBSCO.
    • E-mail ijmmm@ejournal.net

Prof. Ian McAndrew
Capitol Technology University, USA
It is my honor to be the editor-in-chief of IJMMM. I will do my best to work with the editorial team and help make this journal better.

IJMMM 2017 Vol.5(4): 231-234 ISSN: 1793-8198
DOI: 10.18178/ijmmm.2017.5.4.325

Multifunctional Magnetic Iron Oxide Nanoparticles for Intracellular Imaging and Drug Delivery to Cancer Cells

Kheireddine El-Boubbou
Abstract—Nowadays there is a tremendous shift in focus towards developing controlled drug delivery systems using drug-loaded nanomaterials. Of the many available systems, magnetic nanoparticles are considered promising drug-carriers due to their large surface area, ease of synthesis, low toxicity and imaging capability. Herein, we report a simple approach to create a novel chemotherapeutic formulation made of fluorescently-labeled PVPylated magnetic iron oxide nanoparticles loaded with anticancer drugs. Drug loading and release profiles were first studied, showing high loading drug efficiencies and relatively fast release of the cargo from its construct. The delivery of these particles to cancerous cells were then investigated. Whereas the Fl-PVP-MNPs were not toxic to the tested cancerous cells even at high doses, the cells were sensitive to Dox-loaded Fl-PVP-MNPs, effectively killing the cells. We anticipate that the observed potent effect is due to the successful intracellular uptake of the MNPs by cells and the subsequent release of Dox from the NPs, which can then translocate to the nucleus and exert its cytotoxic action. Notably, the MNPs used in this work can potentially open new opportunities for in vivo cancer therapeutic imaging and hyperthermia.

Index Terms—Magnetic nanoparticles, metal oxide, drug delivery, cancer cells.

Kheireddine El-Boubbou is with King Saud bin Abdulaziz University for Health Sciences (KSAU-HS) and King Abdullah International Medical Research Center (KAIMRC), King Abdulaziz Medical City, National Guard Health Affairs, Riyadh 11481, Kingdom of Saudi Arabia (e-mail: elboubboukh@ngha.med.sa; boubbouk@ksau-hs.edu.sa).


Cite: Kheireddine El-Boubbou, "Multifunctional Magnetic Iron Oxide Nanoparticles for Intracellular Imaging and Drug Delivery to Cancer Cells," International Journal of Materials, Mechanics and Manufacturing vol. 5, no. 4, pp. 231-234, 2017.

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